Tripothesis search

Search Tripotheses

Search Tripothesis titles, stable IDs, source terms, and source libraries across the current indexed Tripotheses.

try an example: UBTF, Body Mass Index, GWAS_Catalog_2023

Report collection

Top 25 Tripotheses

Showing 25 generated reports. Source libraries, shared-gene counts, and novelty metrics are omitted here because they are not present in the selected report manifest.

Ranking Strategy

Expand to see how the displayed Top 25 Tripotheses were prioritized from the multi-omics Tripothesis ranking pipeline.

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This strategy explains how the displayed Top 25 Tripotheses were prioritized from the multi-omics Tripothesis ranking pipeline.

1. Multi-omics overlap

Candidate Tripotheses are first formed from three distinct source gene-set libraries. The initial statistical rank favors stronger shared-gene evidence: higher conservative three-way -log10(p-value), then larger three-way overlap size, then higher three-way Jaccard similarity.

2. PubMed novelty

Each source term is mapped to a PubMed search entity. The novelty score rewards concepts that are individually findable in PubMed but sparsely co-mentioned as pairs or as the full three-term combination.

3. Final report selection

The final priority score blends statistical strength with PubMed novelty. The report queue then applies diversity filters so the top 25 are not dominated by repeated terms, library pairs, or highly similar shared-gene overlaps.

Scoring field	How it is used
Statistical priority percentile	The statistical score rewards stronger three-way evidence: smaller conservative p-values, larger shared-gene overlap, and higher Jaccard similarity across the three input sets. The score is calculated as - log p-value + overlap size + 100 * Jaccard score, with additional credit for compact coverage, while being penalized for repeated sources, repeated terms, and common-gene dominance. This statistical score is then converted into a percentile from 0 to 100.
PubMed novelty score	A 0-100 score based on individual PubMed coverage plus scarcity of pairwise and three-way co-mentions.
Novelty-adjusted priority score	Balanced ranking score: 65% statistical priority percentile and 35% PubMed novelty by default.
Diversity filters	Limits repeated traits, regulators, perturbagens, source crossings, central PubMed terms, and near-duplicate shared-gene sets.

No.	Tripothesis title	Three terms	Report
1	Appendicular Lean Mass × UBTF ENCODE × GSE182680,GSE182683 5 V 11 DEXAMETHASONE HUMAN UP	Appendicular Lean Mass UBTF ENCODE GSE182680,GSE182683 5 V 11 DEXAMETHASONE HUMAN UP	View Report
2	Heel Bone Mineral Density × AMD3100 T-cell acute lymphoblastic leukemia (T-ALL) cells GSE60367 up × UBTF ENCODE	Heel Bone Mineral Density AMD3100 T-cell acute lymphoblastic leukemia (T-ALL) cells GSE60367 up UBTF ENCODE	View Report
3	Systolic Blood Pressure × UBTF ENCODE × GSE147876,GSE147877 4 V 10 ENZALUTAMIDE HUMAN DN	Systolic Blood Pressure UBTF ENCODE GSE147876,GSE147877 4 V 10 ENZALUTAMIDE HUMAN DN	View Report
4	Total Cholesterol Levels × AMD3100 T-cell acute lymphoblastic leukemia (T-ALL) cells GSE60367 up × UBTF ENCODE	Total Cholesterol Levels AMD3100 T-cell acute lymphoblastic leukemia (T-ALL) cells GSE60367 up UBTF ENCODE	View Report
5	Body Mass Index × SUZ12 CHEA × GSE113146 EGFR Inhibition 1 V 2 Mouse up	Body Mass Index SUZ12 CHEA GSE113146 EGFR Inhibition 1 V 2 Mouse up	View Report
6	Appendicular Lean Mass × CHD1 ENCODE × GSE100148 EZH2 Inhibition 4 V 5 Human up	Appendicular Lean Mass CHD1 ENCODE GSE100148 EZH2 Inhibition 4 V 5 Human up	View Report
7	Liver Disease Biomarker × SMAD4 19686287 ChIP-ChIP HaCaT Human × RISPERIDONE	Liver Disease Biomarker SMAD4 19686287 ChIP-ChIP HaCaT Human RISPERIDONE	View Report
8	AMD3100 T-cell acute lymphoblastic leukemia (T-ALL) cells GSE60367 up × Basal metabolic rate 23105 raw × UBTF ENCODE	AMD3100 T-cell acute lymphoblastic leukemia (T-ALL) cells GSE60367 up Basal metabolic rate 23105 raw UBTF ENCODE	View Report
9	Basal metabolic rate 23105 raw × UBTF ENCODE × GSE182680,GSE182683 5 V 8 DEXAMETHASONE HUMAN UP	Basal metabolic rate 23105 raw UBTF ENCODE GSE182680,GSE182683 5 V 8 DEXAMETHASONE HUMAN UP	View Report
10	Heel Bone Mineral Density × CDX2 22108803 ChIP-Seq LS180 Human × GSE214596,GSE214598 1 V 2 ROSIGLITAZONE MOUSE DN	Heel Bone Mineral Density CDX2 22108803 ChIP-Seq LS180 Human GSE214596,GSE214598 1 V 2 ROSIGLITAZONE MOUSE DN	View Report
11	Ankle spacing width 3143 raw × FUS 26573619 Chip-Seq HEK293 Human × GSE236454,GSE236456 0 V 1 ANGIOTENSIN II MOUSE DN	Ankle spacing width 3143 raw FUS 26573619 Chip-Seq HEK293 Human GSE236454,GSE236456 0 V 1 ANGIOTENSIN II MOUSE DN	View Report
12	Appendicular Lean Mass × PGR KO MOUSE GSE39920 CREEDSID GENE 3080 UP × Pgr KO mouse GSE39920 sample 3080	Appendicular Lean Mass PGR KO MOUSE GSE39920 CREEDSID GENE 3080 UP Pgr KO mouse GSE39920 sample 3080	View Report
13	AMD3100 T-cell acute lymphoblastic leukemia (T-ALL) cells GSE60367 up × Basal metabolic rate 23105 raw × GATA1 CHEA	AMD3100 T-cell acute lymphoblastic leukemia (T-ALL) cells GSE60367 up Basal metabolic rate 23105 raw GATA1 CHEA	View Report
14	Basal metabolic rate 23105 raw × RUNX1 CHEA × GSE190534,GSE190536 0 V 3 CYCLOPHOSPHAMIDE MOUSE DN	Basal metabolic rate 23105 raw RUNX1 CHEA GSE190534,GSE190536 0 V 3 CYCLOPHOSPHAMIDE MOUSE DN	View Report
15	Body fat percentage 23099 raw × GATA1 CHEA × GSE182680,GSE182683 5 V 8 DEXAMETHASONE HUMAN UP	Body fat percentage 23099 raw GATA1 CHEA GSE182680,GSE182683 5 V 8 DEXAMETHASONE HUMAN UP	View Report
16	Body Mass Index × SOX2 DEFICIENCY HUMAN GSE42937 CREEDSID GENE 347 UP × SOX2 Deficiency human GSE42937 sample 347	Body Mass Index SOX2 DEFICIENCY HUMAN GSE42937 CREEDSID GENE 347 UP SOX2 Deficiency human GSE42937 sample 347	View Report
17	Body Mass Index × CDX2 22108803 ChIP-Seq LS180 Human × GSE147876,GSE147877 4 V 11 ENZALUTAMIDE HUMAN DN	Body Mass Index CDX2 22108803 ChIP-Seq LS180 Human GSE147876,GSE147877 4 V 11 ENZALUTAMIDE HUMAN DN	View Report
18	Body Mass Index × CDX2 22108803 ChIP-Seq LS180 Human × GSE198826,GSE198911 1 V 2 DEXAMETHASONE MOUSE UP	Body Mass Index CDX2 22108803 ChIP-Seq LS180 Human GSE198826,GSE198911 1 V 2 DEXAMETHASONE MOUSE UP	View Report
19	Both eyes present 5182 1 × SUZ12 CHEA × GSE114492 GSE153671 KMT2D Inhibition 2 V 11 Human up	Both eyes present 5182 1 SUZ12 CHEA GSE114492 GSE153671 KMT2D Inhibition 2 V 11 Human up	View Report
20	Systolic Blood Pressure × CEBPD 23245923 ChIP-Seq MEFs Mouse × A549 BISINDOLYLMALEIMIDE IX 10NM 24H DN	Systolic Blood Pressure CEBPD 23245923 ChIP-Seq MEFs Mouse A549 BISINDOLYLMALEIMIDE IX 10NM 24H DN	View Report
21	Systolic Blood Pressure × NUCKS1 24931609 ChIP-Seq HEPATOCYTES Mouse × GSE107288 DCPS Inhibition Granulocyte Monocyte Progenitor Cell RNA Messenger 4 V 2 Mouse up	Systolic Blood Pressure NUCKS1 24931609 ChIP-Seq HEPATOCYTES Mouse GSE107288 DCPS Inhibition Granulocyte Monocyte Progenitor Cell RNA Messenger 4 V 2 Mouse up	View Report
22	Blood Protein Levels × KLF15 DEFICIENCY MOUSE GSE7137 CREEDSID GENE 675 UP × Mouse liver 10 months vs 22 months GSE3150 aging:326	Blood Protein Levels KLF15 DEFICIENCY MOUSE GSE7137 CREEDSID GENE 675 UP Mouse liver 10 months vs 22 months GSE3150 aging:326	View Report
23	Blood Protein Levels × SOX3 KO MOUSE GSE53760 CREEDSID GENE 1668 UP × Sox3 KO mouse GSE53760 sample 1668	Blood Protein Levels SOX3 KO MOUSE GSE53760 CREEDSID GENE 1668 UP Sox3 KO mouse GSE53760 sample 1668	View Report
24	Body fat percentage 23099 raw × SOX3 KO MOUSE GSE53760 CREEDSID GENE 1668 UP × Sox3 KO mouse GSE53760 sample 1668	Body fat percentage 23099 raw SOX3 KO MOUSE GSE53760 CREEDSID GENE 1668 UP Sox3 KO mouse GSE53760 sample 1668	View Report
25	Blood Protein Levels × KLF15 DEFICIENCY MOUSE GSE7137 CREEDSID GENE 675 UP × Ppargc1b Hypomorphic Mutation mouse GSE6210 sample 1191	Blood Protein Levels KLF15 DEFICIENCY MOUSE GSE7137 CREEDSID GENE 675 UP Ppargc1b Hypomorphic Mutation mouse GSE6210 sample 1191	View Report